DUBLIN, Ireland -- Research and Markets (http://www.researchandmarkets.com/reports/c67204) has announced the addition of Liver Cancer Drug Pipeline Update 2007 to their offering.
There are today more than 85 therapeutics targeting liver cancer, from early preclinical to marketed drugs. Liver Cancer Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 58 different targets.
These targets are further categorized on the CD-ROM by 29 classifications of molecular function and their possible belonging to 17 different signaling pathways in the cell. Read more below on how the Liver Cancer Drug Pipeline Update is organized.
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Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below.
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Drug Pipeline Update at a Glance
Investigators Includes more than 80 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.
Drug name & Synonyms Lists commercial, generic and code names for drugs. In all more than 150 names
Developmental stage This Drug Pipeline Update contains more than 85 drugs in active development for the treatment of liver cancer:
* 7 marketed drugs
* 3 drugs in Phase III
* 30 drugs in Phase II
* 20 drugs in Phase I
* 20 drugs in Preclinical
Indications included liver cancer drugs are also in development for over 60 other indications.
Targets Identified drugs are linked to 58 different targets, divided into 29classifications of molecular function:
* Catalytic activity
* Cell adhesion molecule activity
* Cytokine activity
* DNA topoisomerase activity
* DNA-directed DNA polymerase activity
* Extracellular matrix structural constituent
* G-protein coupled receptor activity
* Growth factor activity
* Kinase activity
* Ligase activity
* Molecular function unknown
* Motor activity
* Peptidase activity
* Phosphoric diester hydrolase activity
* Protein binding
* Protein serine/threonine kinase activity
* Protein tyrosine phosphatase activity
* Receptor activity
* Receptor binding
* Receptor signaling complex scaffold activity
* RNA-directed DNA polymerase activity
* Structural constituent of cytoskeleton
* Transcription factor activity
* Transcription regulator activity
* Transferase activity
* Transmembrane receptor activity
* Transmembrane receptor protein tyrosine kinase activity
* Transporter activity
* Unclassified
Identified targets are categorized into 17 different primary and alternate localizations:
* Centrosome
* Clathrin-coated vesicle
* Cytoplasm
* Cytoplasmic vesicle
* Cytoskeleton
* Endoplasmic reticulum
* Endosome
* Extracellular
* Golgi apparatus
* Lysosome
* Mitochondrial membrane
* Mitochondrion
* Nucleolus
* Nucleus
* Perinuclear vesicle
* Plasma membrane
* Secreted
Note: You are able to sort and find drugs according to target name, molecular function of target, and target localization from drop-down menus in the application.
Target Expression Profile Direct links are provided from inside the application to protein expression profiles of 27 drug targets in various human tissues, cell lines and primary cells, including up to:
- 48 different normal tissue types
- 20 different types of cancer
- 47 cell lines
- 12 samples of primary blood cells
Targeted Signaling Pathways Identified targets have been cross referenced against 20 signaling pathways, and no less than 17 are currently being pursued in liver cancer drug development:
* Alpha6 Beta4 Integrin Signaling Pathway
* Androgen Receptor Signaling Pathway
* B Cell Receptor Signaling Pathway
* EGFR1 Signaling Pathway
* ID Signaling Pathway
* IL-1 Signaling Pathway
* IL-2 Signaling Pathway
* IL-3 Signaling Pathway
* IL-4 Signaling Pathway
* IL-5 Signaling Pathway
* IL-6 Signaling Pathway
* IL-7 Signaling Pathway
* Kit Receptor Signaling Pathway
* Notch Signaling Pathway
* T Cell Receptor Signaling Pathway
* TGF-beta Receptor Signaling Pathway
* TNF-alpha Signaling Pathway
Mechanism In total there are at least 62 different drug mechanism of action represented in this Drug Pipeline Update.
Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.
Compound Identified drug compounds are described by:
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